Structural considerations in the fitness landscape of a virus.
نویسندگان
چکیده
Viral fitness is determined by replication within hosts and transmission between them. We examine how pleiotropic mutations that have antagonistic effects (i.e., antibody evasion vs. receptor binding) on viral replication within hosts can impact viral immune escape in the host population. When the host population is vaccinated, the virus escapes from passive immunity by mutations in the antibody-binding region on the surface of the target protein. However, the reduced ability of the antibody to bind the virus is often accompanied by a reduced ability of the virus to bind the cell receptor because the antibody-binding region overlaps with the receptor-binding domain (RBD). The types of permitted mutations are limited. To investigate the causal relation between a mutation in a viral genome and adaptive evolution of a viral population, we developed a mathematical model that describes the population dynamics of viruses, antibodies, and normal/infected cells within a host. The coefficients describe the binding affinity between the virus and the induced antibody and that between the virus and its receptor. Our knowledge-based index enables us to estimate the effect of a mutation in a binding region on the binding affinity. Using population genetic theory, we evaluated the probability that a mutant is fixed in a host population. The mutations that can be fixed with high probabilities may determine how long a vaccine remains effective. We simulate the adaptive evolution of coronavirus, the etiological agent of severe acute respiratory syndrome, and show that some of mutations in the RBD may have high fixation probabilities in the vaccinated host population.
منابع مشابه
مقایسه تطبیقی باغ های تخت شیراز و قصر قجر تهران
This research pursues the cognition Architectural and Landscape characteristics of gardens of Ghasre Ghajar of Tehran and Takht of Shiraz, also trying to attain structural ـ essential patterns in both and the ways these two relate to each other, with the aim of revitalizing the patterns of terraced garden and then implementing in new Architectural ـ Landscape projects. This attempt is justifi...
متن کاملSome Considerations on Climatic Geomorphology of the Romanian Territory
The main issues about relation between climate and relief in the Romanian geomorphological literature follow three directions of research: the description of Pleistocene glacial and Pleistocene-Holocene periglacial landforms in the Carpathians; the direct analysis of climate?s role in landform development; the integration of separate works and findings in a synthetic morphodynamic system applic...
متن کاملAssessment and Comparison of Landscape Connectivity in KoozehTopraghi Watershed, Ardabil Province
Following the unbalanced development and overexploitation of the country's watersheds, land fragmentation has become a major concern for the conservation of ecosystem services and land health. For this purpose, the present study was planned to evaluate and compare the landscape connectivity indices of KoozehTopraghi Watershed as one of the ecologically susceptible watersheds located in Ardabil ...
متن کاملبارداری و شغل
Introduction: Pregnant employees demand special attention from their employers and themselves. In this study,the focus is on the interaction between pregnancy and occupation. Methods: This study was a review article. Authentic articles, sites and books on occupational medicine, fitness for work and obstetrics were used. This study consisted of different parts including: definition of terms, th...
متن کاملReflections on Researching the Rugged Fitness Landscape
The success of an informing system depends upon achieving a fit between multiple entities: the sender, the client, the delivery system, and the task to be performed. Conceptually, the effectiveness of such informing can be modeled as a fitness landscape—a function that maps the characteristics of the system into a scalar fitness value. The assumed shape of that landscape plays a major role in d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecular biology and evolution
دوره 27 8 شماره
صفحات -
تاریخ انتشار 2010